Background:

This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants.

Applications:

WB, IHC

Name of antibody:

GUCY1B3

Immunogen:

Synthesized peptide derived from human Guanylate Cyclase β.

Full name:

guanylate cyclase 1, soluble, beta 3

Synonyms：

GUCB3; GC-SB3; GUC1B3; GUCSB3; GUCY1B1; GC-S-beta-1

SwissProt:

Q02153

IHC positive control:

Human lung carcinoma tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

71 kDa

WB Positive control:

Huvec cells lysate

WB Recommended dilution:

500-3000