Background:

This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Applications:

WB, IHC

Name of antibody:

MAPKAPK2(Phospho-Ser272)

Immunogen:

Peptide sequence around phosphorylation site of Serine 272(A-I-S(p)-P-G) derived from Human MAPKAPK2.

Full name:

mitogen-activated protein kinase-activated protein kinase 2

Synonyms：

MK2; MK-2; MAPKAP-K2

SwissProt:

P49137

IHC positive control:

Human brain tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

46 kDa

WB Positive control:

RAW264.7 cells lysates treated with UV

WB Recommended dilution:

500-1000