Background:

This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.

Applications:

ELISA, WB, IHC

Name of antibody:

MASP1

Immunogen:

Fusion protein of human MASP1

Full name:

mannan binding lectin serine peptidase 1

Synonyms:

3MC1; MAP1; MASP; RaRF; CRARF; MASP3; MAp44; PRSS5; CRARF1

SwissProt:

P48740

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human prostate cancer and Human breast cancer

IHC Recommend dilution:

100-300

WB Predicted band size:

79 kDa

WB Positive control:

Human heart tissue and Hela cell lysates

WB Recommended dilution:

500-2000