Background:

This gene encodes the large subunit of 3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Mutations in this gene are associated with 3-Methylcrotonylglycinuria, an autosomal recessive disorder of leucine catabolism.

Applications:

ELISA, WB, IHC

Name of antibody:

MCCC1

Immunogen:

Fusion protein of human MCCC1

Full name:

methylcrotonoyl-CoA carboxylase 1

Synonyms:

MCCA; MCC-B

SwissProt:

Q96RQ3

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human cervical cancer

IHC Recommend dilution:

40-200

WB Predicted band size:

80 kDa

WB Positive control:

293T, HepG2, A172 cell, Mouse heart tissue, Jurkat cell lysates

WB Recommended dilution:

500-2000